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Year : 2022  |  Volume : 10  |  Issue : 2  |  Page : 162-166

Expression of human epidermal growth factor receptor 2/Neu in oral leukoplakia

1 Department of General Surgery, AIIMS, Patna, Bihar, India
2 Department of General Surgery and Pathology, Dr. BSA Medical College and Hospital, Rohini, Delhi, India
3 Department of Pathology, Dr. BSA Medical College and Hospital, Rohini, Delhi, India
4 Department of ENT, PGIMS, Rohtak, Haryana, India

Correspondence Address:
Ashesh Kumar Jha
Department of General Surgery, AIIMS, Patna, Bihar
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jhnps.jhnps_41_22

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Background: Molecular alterations in premalignant lesions of the oral cavity are not well known. Many reports have found increased human epidermal growth factor receptor 2 (HER-2) expression in oral cancer. Overexpression of HER-2 in premalignant lesions may denote its positive contribution in the malignant transformation of these lesions. Materials and Methods: Twenty-three samples of leukoplakia were stained by routine H and E to assess any dysplasia; five samples of normal mucosa were used as control. Immunohistochemical staining for HER-2 was done. ASCO/CAP 2018 guidelines were used for reporting the results. The percentage of lesions expressing cytoplasmic or membranous expression was calculated. Results: One sample of leukoplakia with severe dysplasia expressed focal membranous staining. Cytoplasmic staining was observed in 3/9 (33.33%) dysplastic leukoplakia. Only one nondysplastic leukoplakia expressed cytoplasmic HER-2 staining. Conclusions: Membranous expression in severe dysplasia and higher expression in oral cancer are in concordance with the multistep theory of carcinogenesis.

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